The neural basis of sustained and transient attentional control in young adults with ADHD

被引：81

作者：

Banich, Marie T. ^{[1
]}

Burgess, Gregory C. ^{[1
]}

Depue, Brendan E. ^{[1
]}

Ruzic, Luka ^{[1
]}

Bidwell, L. Cinnamon ^{[1
]}

Hitt-Laustsen, Sena ^{[1
]}

Du, Yiping P. ^{[1
]}

Willcutt, Erik G. ^{[1
]}

机构：

[1] Univ Colorado, Inst Cognit Sci, Boulder, CO 80309 USA

来源：

NEUROPSYCHOLOGIA | 2009年 / 47卷 / 14期

关键词：

ADHD; fMRI; Prefrontal cortex; Executive function; Attention; Stroop; Young adults; DEFICIT HYPERACTIVITY DISORDER; ANTERIOR CINGULATE CORTEX; EVENT-RELATED FMRI; DEFICIT/HYPERACTIVITY DISORDER; STROOP-TASK; RESPONSE COMPETITION; WORKING-MEMORY; INTERFERENCE; BRAIN; DYSFUNCTION;

D O I：

10.1016/j.neuropsychologia.2009.07.005

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Differences in neural activation during performance on an attentionally demanding Stroop task were examined between 23 young adults with ADHD carefully selected to not be co-morbid for other psychiatric disorders and 23 matched controls. A hybrid blocked/single-trial design allowed for examination of more sustained vs. more transient aspects of attentional control. Our results indicated neural dysregulation across a wide range of brain regions including those involved in overall arousal, top-down attentional control, response selection, and inhibition. Furthermore, this dysregulation was most notable in lateral regions of DLPFC for sustained attentional control and in medial areas for transient aspects of attentional control. Because of the careful selection and matching of our two groups, these results provide strong evidence that the neural systems of attentional control are dysregulated in young adults with ADHD and are similar to dysregulations seen in children and adolescents with ADHD. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3095 / 3104

页数：10

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