Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient

被引：16

作者：

Andrei, G.

Fiten, P.

Goubau, P.

van Landuyt, H.

Gordts, B.

Selleslag, D.

de Clercq, E.

Opdenakker, G.

Snoeck, R.

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Virol Lab, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Rega Inst Med Res, Immunol Lab, B-3000 Louvain, Belgium

[3] Catholic Univ Louvain, Hop Univ St Luc, B-1200 Brussels, Belgium

[4] Akad Ziekenhuis St Jan, Brugge, Belgium

来源：

TRANSPLANT INFECTIOUS DISEASE | 2007年 / 9卷 / 02期

关键词：

polyomaviruses; herpesviruses; resistance; cidofovir; hemorrhagic cystitis; stem cell transplant;

D O I：

10.1111/j.1399-3062.2006.00186.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype.

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页码：126 / 131

页数：6

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