SERUM BILIRUBIN LEVELS AND CARDIOVASCULAR DISEASE RISK: A JANUS BIFRONS?

被引：66

作者：

Franchini, Massimo ^{[1
]}

Targher, Giovanni ^{[2
]}

Lippi, Giuseppe ^{[3
]}

机构：

[1] Azienda Osped Univ Parma, Serv Immunoematol & Med Trasfus, Dipartimento Patol & Med Lab, Parma, Italy

[2] Univ Verona, Dipartimento Sci Biomed & Chirurg, Sez Endocrinol, I-37100 Verona, Italy

[3] Azienda Osped Univ Parma, Lab Anal Chim Clin, Dipartimento Patol & Med Lab, Parma, Italy

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 50 | 2010年 / 50卷

关键词：

LOW-DENSITY-LIPOPROTEIN; GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; ALBUMIN-BOUND BILIRUBIN; ISCHEMIC-HEART-DISEASE; UNCONJUGATED BILIRUBIN; CEREBRAL-ISCHEMIA; GILBERTS-SYNDROME; HEME OXYGENASE-2; BILE-PIGMENTS;

D O I：

10.1016/S0065-2423(10)50003-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

This review examines in vitro and in vivo studies, indicating that bilirubin inhibits lipid oxidation and oxygen radical formation. Experimental and epidemiological evidence is presented that suggests that bilirubin may serve as a physiological antioxidant providing protection against cardiovascular disease. Special attention is focused on large prospective studies that noted a strong, inverse relationship between serum bilirubin concentrations and cardiovascular morbidity and mortality even after adjustment for traditional risk factors. Overall, the evidence from these studies suggests that bilirubin, via its antioxidant potential, has antiatherogenic properties, and that serum bilirubin concentrations in the upper portion of the reference interval for the general population may provide some protection against cardiovascular disease, whereas concentrations in the lower portion of the reference interval indicate increased cardiovascular risk.

引用

页码：47 / 63

页数：17

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