A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus

被引:171
作者
Biek, Roman
Henderson, J. Caroline
Waller, Lance A.
Rupprecht, Charles E.
Real, Leslie A.
机构
[1] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
[2] Emory Univ, Ctr Dis Ecol, Atlanta, GA 30322 USA
[3] Ctr Dis Control & Prevent, Rabies Sect, Atlanta, GA 30333 USA
[4] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat, Atlanta, GA 30322 USA
关键词
invasion; phylogeography; Procyon lotor; wildlife disease; zoonoses;
D O I
10.1073/pnas.0700741104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Emerging pathogens potentially undergo rapid evolution while expanding in population size and geographic range during the course of invasion, yet it is generally difficult to demonstrate how these processes interact. Our analysis of a 30-yr data set covering a large-scale rabies virus outbreak among North American raccoons reveals the long lasting effect of the initial infection wave in determining how viral populations are genetically structured in space. We further find that coalescent-based estimates derived from the genetic data yielded an amazingly accurate reconstruction of the known spatial and demographic dynamics of the virus overtime. Our study demonstrates the combined evolutionary and population dynamic processes characterizing the spread of pathogen after its introduction into a fully susceptible host population. Furthermore, the results provide important insights regarding the spatial scale of rabies persistence and validate the use of coalescent approaches for uncovering even relatively complex population histories. Such approaches will be of increasing relevance for understanding the epidemiology of emerging zoonotic diseases in a landscape context.
引用
收藏
页码:7993 / 7998
页数:6
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