Itraconazole-amphotericin B antagonism in Aspergillus fumigatus:: an E-test-based strategy

被引：63

作者：

Kontoyiannis, DP

Lewis, RE

Sagar, N

May, G

Prince, RA

Rolston, KVI

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Internal Med Specialties, Infect Dis Sect, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Div Pathol, Houston, TX 77030 USA

[3] Univ Houston, Coll Pharm, Houston, TX 77204 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期

关键词：

D O I：

10.1128/AAC.44.10.2915-2918.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We examined an E-test-based strategy for testing the combination of itraconazole and amphotericin B, the latter given either sequentially or concomitantly, in isolates of Aspergillus fumigatus. An antagonistic interaction between the two drugs was noted, especially with the sequential administration of amphotericin B. This in vitro antagonism was reversible.

引用

页码：2915 / 2918

页数：4

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