Environment-sensitive two-photon probe for intracellular free magnesium ions in live tissue

被引:152
作者
Kim, Hwan Myung
Jung, Cheol
Kim, Bo Ra
Jung, Soon-Young
Hong, Jin Hee
Ko, Young-Gyu
Lee, Kyoung J.
Cho, Bong Rae
机构
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Korea Univ, Ctr Electro & Photorespons Mol, Seoul 136701, South Korea
[3] Korea Univ, Grad Sch Life Sci & Biotechnol, Seoul 136701, South Korea
[4] Korea Univ, Dept Phys, Seoul 136701, South Korea
[5] Korea Univ, Natl Creat Res Initiat Ctr Neurodynam, Seoul 136701, South Korea
关键词
fluorescent probes; imaging agents; magnesium; two-photon processes;
D O I
10.1002/anie.200700169
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Figure Presented) Green" emission: A novel two-photon fluorescent probe that can detect intracellular free Mg2+ ions at a depth of a few hundred micrometers in live tissue was developed. The emission from the Mg2+-probe complex (green) shows little interference from association of the probe with other intracellular metal ions or with the cell membrane (blue). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA."
引用
收藏
页码:3460 / 3463
页数:4
相关论文
共 25 条
[1]   Molecular two-photon sensor for metal ions derived from bis(2-pyridyl)amine [J].
Ahn, HC ;
Yang, SK ;
Kim, HM ;
Li, SJ ;
Jeon, SJ ;
Cho, BR .
CHEMICAL PHYSICS LETTERS, 2005, 410 (4-6) :312-315
[2]  
[Anonymous], 2005, INVITROGEN MOL PROBE
[3]  
[Anonymous], MAGNESIUM CELL
[4]   A SPECTROPHOTOMETRIC INVESTIGATION OF THE INTERACTION OF IODINE WITH AROMATIC HYDROCARBONS [J].
BENESI, HA ;
HILDEBRAND, JH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1949, 71 (08) :2703-2707
[5]   Transmembrane calcium influx induced by ac electric fields [J].
Cho, MR ;
Thatte, HS ;
Silvia, MT ;
Golan, DE .
FASEB JOURNAL, 1999, 13 (06) :677-683
[6]   Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions [J].
Eskes, R ;
Antonsson, B ;
Osen-Sand, A ;
Montessuit, S ;
Richter, C ;
Sadoul, R ;
Mazzei, G ;
Nichols, A ;
Martinou, JC .
JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :217-224
[7]   8-Hydroxyquinoline derivatives as fluorescent sensors for magnesium in living cells [J].
Farruggia, G ;
Iotti, S ;
Prodi, L ;
Montalti, M ;
Zaccheroni, N ;
Savage, PB ;
Trapani, V ;
Sale, P ;
Wolf, FI .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (01) :344-350
[8]   REGULATION OF CATION CHANNELS IN LIVER-CELLS BY INTRACELLULAR CALCIUM AND PROTEIN-KINASE-C [J].
FITZ, JG ;
SOSTMAN, AH ;
MIDDLETON, JP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (04) :G677-G684
[9]   Deep tissue two-photon microscopy [J].
Helmchen, F ;
Denk, W .
NATURE METHODS, 2005, 2 (12) :932-940
[10]   A practical guide for the determination of binding constants [J].
Hirose, K .
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2001, 39 (3-4) :193-209