Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer

被引：75

作者：

Kanazawa, Y

Isomoto, H

Oka, M

Yano, Y

Soda, H

Shikuwa, S

Takeshima, F

Omagari, K

Mizuta, Y

Murase, K

Nakagoe, T

Ohtsuka, K

Kohno, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 852, Japan

[3] Natl Nagasaki Med Ctr, Dept Endoscopy, Omura, Japan

[4] Chubu Univ, Coll Biosci & Biotechnol, Lab Cell & Stress Biol, Kasugai, Aichi 487, Japan

来源：

MEDICAL ONCOLOGY | 2003年 / 20卷 / 02期

关键词：

Hsp; 70; 40; colorectal cancer; immunohistochemistry; immunoblot;

D O I：

10.1385/MO:20:2:157

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Heat shock protein (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. The present study was designed to determine the expression levels of Hsp 70 and Hsp 40 in colorectal cancer by immunohistochemistry and Western blot analysis. Among 50 colorectal cancer tissues studied, 80% and 14% of tumors showed specific immunoreactivity to Hsp 70 and Hsp 40, respectively. Hsp 70 and Hsp 40 were overexpressed in cancer tissue samples compared with normal tissues, on both analytic sets. However, there were no significant correlations between their expression and various clinicopathological parameters of colorectal cancer. Hsp 70 and Hsp 40 may be tumor markers for colorectal cancer.

引用

页码：157 / 164

页数：8

共 25 条

[1]

ABD EI, 1998, ANTICANCER RES, V18, P1533

[2]

EXPRESSION OF HEAT-SHOCK PROTEINS IN HUMAN LUNG AND LUNG CANCERS [J].