Single oral dose of geranylgeranylacetone for protection against delayed neuronal death induced by transient ischemia

被引：14

作者：

Fujiki, M ^{[1
]}

Kobayashi, H ^{[1
]}

Inoue, R ^{[1
]}

Abe, T ^{[1
]}

Ishii, K ^{[1
]}

机构：

[1] Oita Univ, Sch Med, Dept Neurosurg, Hasamamachi, Oita 8795593, Japan

来源：

BRAIN RESEARCH | 2004年 / 1020卷 / 1-2期

关键词：

geranylgeranylacetone; cerebral ischemia; neuronal death; hippocampus; neuroprotection; gerbil; HSP;

D O I：

10.1016/j.brainres.2004.06.031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The present study evaluated the potential effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent, against the delayed neuronal death (DND) of hippocampal neurons an otherwise lethal ischemic insult. Pretreatment with single oral GGA (800 mg/kg, 2 days before ischemia) significantly attenuated DND in gerbil hippocampus. These effects of GGA were prevented by the coinjection of MK801, a noncompetitive N-methyl-D-aspartate glutamate receptor antagonist, which indicates that the protection was indeed glutamate receptor activation mediated. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：210 / 213

页数：4

共 22 条

[1]

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration [J].

Akbar, MT ;

Wells, DJ ;

Latchman, DS ;

de Belleroche, J .

MOLECULAR BRAIN RESEARCH, 2001, 93 (02) :148-163

[2]

Proposed mechanism for induction of heat shock protein 70 by geranylgeranyl acetone by prenylation of Ras proteins [J].

Bar-Or, D .

CRITICAL CARE MEDICINE, 2003, 31 (11) :2700-2701

[3]

SPREADING DEPRESSION AND REVERBERATORY SEIZURES INDUCE THE UP-REGULATION OF MESSENGER-RNA FOR GLIAL FIBRILLARY ACIDIC PROTEIN [J].

BONTHIUS, DJ ;

STRINGER, JL ;

LOTHMAN, EW ;

STEWARD, O .

BRAIN RESEARCH, 1994, 645 (1-2) :215-224

[4]

Astroglial activation accompanies heat shock protein upregulation in rat brain following single oral dose of geranylgeranylacetone [J].

Fujiki, M ;

Kobayashi, H ;

Abe, T ;

Ishii, K .

BRAIN RESEARCH, 2003, 991 (1-2) :254-257

[5]

GILL R, 1987, J NEUROSCI, V7, P3343

[6]

Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa [J].

Hirakawa, T ;

Rokutan, K ;

Nikawa, T ;

Kishi, K .

GASTROENTEROLOGY, 1996, 111 (02) :345-357

[7]

Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance [J].

Kawahara, N ;

Croll, SD ;

Wiegand, SJ ;

Klatzo, I .

NEUROSCIENCE RESEARCH, 1997, 29 (01) :37-47

[8]

Kirino T, 1996, ADV NEUROL, V71, P505

[9]

ISCHEMIC TOLERANCE PHENOMENON DETECTED IN VARIOUS BRAIN-REGIONS [J].

KITAGAWA, K ;

MATSUMOTO, M ;

KUWABARA, K ;

TAGAYA, M ;

OHTSUKI, T ;

HATA, R ;

UEDA, H ;

HANDA, N ;

KIMURA, K ;

KAMADA, T .

BRAIN RESEARCH, 1991, 561 (02) :203-211

[10]

Protein kinase C modulates NMDA receptor trafficking and gating [J].

Lan, JY ;

Skeberdis, VA ;

Jover, T ;

Grooms, SY ;

Lin, Y ;

Araneda, RC ;

Zheng, X ;

Bennett, MVL ;

Zukin, RS .

NATURE NEUROSCIENCE, 2001, 4 (04) :382-390

← 1 2 3 →