Origin DNA-binding proteins

被引：22

作者：

Edwards, AM

Bochkarev, A

Frappier, L

机构：

[1] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-440X(98)80009-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first step in DNA replication involves the recognition of origin DNA sequences by origin-binding proteins. The three-dimensional structures of three different origin DNA-binding proteins have recently been solved. These proteins form a structural class distinct from other DNA-binding proteins. One of the origin-binding proteins, Epstein-Barr virus nuclear antigen 1, most likely has two modes of DNA binding; the sequential use of these modes may be important for the initiation of DNA replication.

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页码：49 / 53

页数：5

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