Conjuring SNPs to detect associations

被引：22

作者：

Clark, Andrew G. ^{[1
]}

Li, Jian ^{[1
]}

机构：

[1] Cornell Univ, Dept Genet & Mol Biol, Ithaca, NY 14853 USA

来源：

NATURE GENETICS | 2007年 / 39卷 / 07期

关键词：

D O I：

10.1038/ng0707-815

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human genome-wide association studies pose a challenge in identifying significant disease associations from nearly half a million statistical tests. A new report describes an especially promising approach, recently applied to the Wellcome Trust Case Control Consortium data sets, that uses the correlated structure of genomic variation to impute genotypes at missing sites and to test association with both observed and imputed SNPs.

引用

页码：815 / 816

页数：2

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