Long-chain formoterol analogues:: an investigation into the effect of increasing amino-substituent chain length on the β2-adrenoceptor activity

被引：41

作者：

Alikhani, V ^{[1
]}

Beer, D ^{[1
]}

Bentley, D ^{[1
]}

Bruce, I ^{[1
]}

Cuenoud, BM ^{[1
]}

Fairhurst, RA ^{[1
]}

Gedeck, P ^{[1
]}

Haberthuer, S ^{[1
]}

Hayden, C ^{[1
]}

Janus, D ^{[1
]}

Jordan, L ^{[1
]}

Lewis, C ^{[1
]}

Smithies, K ^{[1
]}

Wissler, E ^{[1
]}

机构：

[1] Novartis Horsham Res Ctr, Horsham RH12 5AB, W Sussex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

D O I：

10.1016/j.bmcl.2004.06.086

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4705 / 4710

页数：6

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