Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004)

被引：32

作者：

Ednie, LM

Jacobs, MR

Appelbaum, PC

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PATHOL CLIN MICROBIOL,HERSHEY,PA 17033

[2] CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 09期

关键词：

D O I：

10.1128/AAC.41.9.2019

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICS at which 50% of the strains are inhibited (MIC(50)s) of 0.06 to 0.125 mu g/ml and MIC(90)s of 16.0 mu g/ml against 352 anaerobes. MIC(50)s and MIC(90)s of erythromycin, azithromycin, clarithromycin, and roxithromycin were 0.5 to 2.0 mu g/ml and 32.0 to >64.0 mu g/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragilis-group anaerobes (other than Fusobacterium mortiferum, Fasobacterium varium and Clostridium difficile).

引用

页码：2019 / 2022

页数：4

共 10 条

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[2]

GEORGE WL, 1981, REV INFECT DIS, V3, P599

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