POEMS syndrome demonstrating VEGF decrease by ticlopidine

被引：11

作者：

Matsui, H ^{[1
]}

Udaka, F ^{[1
]}

Kubori, T ^{[1
]}

Oda, M ^{[1
]}

Nishinaka, K ^{[1
]}

Kameyama, M ^{[1
]}

机构：

[1] Sumitomo Hosp, Dept Neurol, Kita Ku, Osaka 5300005, Japan

来源：

INTERNAL MEDICINE | 2004年 / 43卷 / 11期

关键词：

POEMS syndrome; vascular endothelial growth factor; ticlopidine;

D O I：

10.2169/internalmedicine.43.1082

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

POEMS syndrome is a syndrome that presents with polyneuropathy, organomegaly, endocrinopathy, M-proteins and skin changes. Elevated vascular endothelial growth factor (VEGF) has recently been reported in POEMS syndrome. We report a case of POEMS syndrome with high VEGF titers. Steroid, plasmapheresis and intravenous gamma-globulin had little effect. Various immunosuppressive agents were discontinued due to side effects. Although administration of aspirin did not decrease VEGF, ticlopidine decreased VEGF significantly. This case suggests that ticlopidine is a candidate for supportive therapy in POEMS syndrome and we should measure VEGF before and after the administration of ticlopidine in other cases.

引用

页码：1082 / 1083

页数：2

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