Does the intrinsic instability of aneuploid genomes have a causal role in cancer?

被引：78

作者：

Matzke, MA ^{[1
]}

Mette, MF ^{[1
]}

Kanno, T ^{[1
]}

Matzke, AJM ^{[1
]}

机构：

[1] Austrian Acad Sci, Inst Mol Biol, A-5020 Salzburg, Austria

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 05期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0168-9525(03)00057-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The role of aneuploidy in carcinogenesis has long been debated. We argue here that aneuploid genomes are naturally more susceptible to the types of chromosome rearrangement and epigenetic aberration that are found typically in tumor cells. In some cases, the formation of an aneuploid genome might be the initiating step in neoplastic conversion.

引用

页码：253 / 256

页数：4

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