Histone variants: deviants?

被引:272
作者
Kamakaka, RT [1 ]
Biggins, S
机构
[1] NIH, UCT, Bethesda, MD 20892 USA
[2] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA
关键词
D O I
10.1101/gad.1272805
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specific functions. in addition, we review histone variant assembly into chromatin, the structure of the variant chromatin, and post-translational modifications that occur on the variants.
引用
收藏
页码:295 / 310
页数:16
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