Antioxidant activity of isoacteoside from Clerodendron trichotomum

被引：28

作者：

Chae, S

Kim, JS

Kang, KA ^{[1
]}

Bu, HD

Lee, Y

Seo, YR

Hyun, JW

Kang, SS

机构：

[1] Seoul Natl Univ, Nat Prod Res Inst, Seoul 110460, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea

[3] Jeju Natl Univ, Coll Med, Dept Biochem, Jeju Do, South Korea

[4] Jeju Natl Univ, Coll Med, Dept Histol, Jeju Do, South Korea

[5] Jeju Natl Univ, Appl Radiol Sci Res Inst, Jeju Do, South Korea

[6] Kyung Hee Univ, Coll Med, Dept Pharmacol, Seoul, South Korea

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES | 2005年 / 68卷 / 05期

关键词：

D O I：

10.1080/15287390590900750

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sub-G, hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.

引用

页码：389 / 400

页数：12

共 36 条

[1]

Ahn, 2003, ILLUSTRATED BOOK KOR, P323

[2]

BAE KH, 2000, MED PLANTA KOREA, P429

[3]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[4]

CARMICHAEL J, 1987, CANCER RES, V47, P936