Radical-induced opening of trisubstituted epoxides:: Application in the synthesis of C1-C12 segment of epothilones

被引：39

作者：

Chakraborty, TK ^{[1
]}

Dutta, S ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 1-2期

关键词：

D O I：

10.1016/S0040-4039(97)10442-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereo- and regioselective opening of a trisubstituted epoxy ketone at the more substituted carbon using samarium(II) iodide presents an alternate approach to the C-5-C-7 aldol moiety with beta-hydroxyketo framework in the stereoselective synthesis of C-1-C-12 segment of epothilones. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

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