Insulin, Insulin Resistance, Obesity, and Cancer

被引：69

作者：

Gallagher, Emily Jane ^{[1
]}

LeRoith, Derek ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Endocrinol, New York, NY 10029 USA

来源：

CURRENT DIABETES REPORTS | 2010年 / 10卷 / 02期

关键词：

Insulin; Insulin-like growth factor-1; Obesity; Cancer; Diabetes; EPITHELIAL OVARIAN-CANCER; BODY-MASS INDEX; GROWTH-FACTOR-I; DIABETES-MELLITUS; BREAST-CANCER; PANCREATIC-CANCER; COLORECTAL-CANCER; RISK-FACTORS; METFORMIN; MORTALITY;

D O I：

10.1007/s11892-010-0101-y

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Epidemiologic studies have proposed a link between obesity, type 2 diabetes, and cancer. The pathophysiologic mechanisms involved in the development of type 2 diabetes, namely hyperinsulinemia and insulin resistance, have also been implicated in cancer development. Patients with type 2 diabetes are reported to have a worse response to cancer chemotherapy, have more complications, and have a poorer prognosis than patients with cancer without diabetes. Studies also have reported that insulin, insulin secretagogues, and metformin may have effects on tumor growth. Given the escalating worldwide prevalence of obesity and type 2 diabetes, their relationship to cancer has generated great interest and research across many fields of medicine.

引用

页码：93 / 100

页数：8

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