Protein acetylation: more than chromatin modification to regulate transcription

被引：24

作者：

Bayle, JH

Crabtree, GR ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Beckman Ctr Mol & Genet Med,Dept Pathol, Palo Alto, CA 94305 USA

[2] Stanford Univ, Sch Med, Howard Hughes Med Inst, Beckman Ctr Mol & Genet Med,Dept Dev Biol, Palo Alto, CA 94305 USA

来源：

CHEMISTRY & BIOLOGY | 1997年 / 4卷 / 12期

关键词：

D O I：

10.1016/S1074-5521(97)90296-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone acetyltransferases and deacetylases are involved In the regulation of gene transcription. Recently, tumor suppressor protein p53 has been shown to be a target for transcriptional coactivators that have histone acetyltransferase activity, suggesting acetylation is also involved in the regulation of cell proliferation and tumorigenesis.

引用

页码：885 / 888

页数：4

共 26 条

[1] Recruitment of p300/CBP in p53-dependent signal pathways [J].

Avantaggiati, ML ;

Ogryzko, V ;

Gardner, K ;

Giordano, A ;

Levine, AS ;

Kelly, K .

CELL, 1997, 89 (07) :1175-1184

[2] THE CARBOXYL-TERMINAL DOMAIN OF THE P53 PROTEIN REGULATES SEQUENCE-SPECIFIC DNA-BINDING THROUGH ITS NONSPECIFIC NUCLEIC ACID-BINDING ACTIVITY [J].

BAYLE, JH ;

ELENBAAS, B ;

LEVINE, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) :5729-5733

[3] TRANSCRIPTIONAL SILENCING IN YEAST IS ASSOCIATED WITH REDUCED NUCLEOSOME ACETYLATION [J].

BRAUNSTEIN, M ;

ROSE, AB ;

HOLMES, SG ;

ALLIS, CD ;

BROACH, JR .

GENES & DEVELOPMENT, 1993, 7 (04) :592-604

[4] Tetrahymena histone acetyltransferase A: A homolog to yeast Gcn5p linking histone acetylation to gene activation [J].

Brownell, JE ;

Zhou, JX ;

Ranalli, T ;

Kobayashi, R ;

Edmondson, DG ;

Roth, SY ;

Allis, CD .

CELL, 1996, 84 (06) :843-851

[5] Histone acetylation in chromatin structure and transcription [J].

Grunstein, M .

NATURE, 1997, 389 (6649) :349-352

[6] Synergistic activation of transcription by CBP and p53 [J].

Gu, W ;

Shi, XL ;

Roeder, RG .

NATURE, 1997, 387 (6635) :819-823

[7]

GU W, 1997, EMBO J, V90, P595

[8] CORE HISTONE HYPERACETYLATION CO-MAPS WITH GENERALIZED DNASE-I SENSITIVITY IN THE CHICKEN BETA-GLOBIN CHROMOSOMAL DOMAIN [J].

HEBBES, TR ;

CLAYTON, AL ;

THORNE, AW ;

CRANEROBINSON, C .

EMBO JOURNAL, 1994, 13 (08) :1823-1830

[9] SMALL PEPTIDES ACTIVATE THE LATENT SEQUENCE-SPECIFIC DNA-BINDING FUNCTION OF P53 [J].

HUPP, TR ;

SPARKS, A ;

LANE, DP .

CELL, 1995, 83 (02) :237-245

[10] REGULATION OF THE SPECIFIC DNA-BINDING FUNCTION OF P53 [J].

HUPP, TR ;

MEEK, DW ;

MIDGLEY, CA ;

LANE, DP .

CELL, 1992, 71 (05) :875-886

← 1 2 3 →