SET domain proteins modulate chromatin domains in eu- and heterochromatin

被引:317
作者
Jenuwein, T
Laible, G
Dorn, R
Reuter, G
机构
[1] Inst Mol Pathol, Res Inst Mol Pathol, A-1030 Vienna, Austria
[2] Univ Halle Wittenberg, Genet Inst, D-06108 Halle, Germany
关键词
SET domain; Pc-G and trx-G genes; PEV in Drosophila; telomeric silencing; Su(var) and E(var) genes; chromatin domains;
D O I
10.1007/s000180050127
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The SET domain is a 130-amino acid, evolutionarily conserved sequence motif present in chromosomal proteins that function in modulating gene activities from yeast to mammals. Initially identified as members of the Polycomb- and trithorax-group (Pc-G and trx-G) gene families, which are required to maintain expression boundaries of homeotic selector (HOM-C) genes, SET domain proteins are also involved in position-effect-variegation (PEV), telomeric and centromeric gene silencing, and possibly in determining chromosome architecture. These observations implicate SET domain proteins as multifunctional chromatin regulators with activities in both eu-and heterochromatin - a role consistent with their modular structure, which combines the SET domain with additional sequence motifs of either a cysteine-rich region/zinc-finger type or the chrome domain. Multiple functions for chromatin regulators are not restricted to the SET protein family, since many trx-G (but only very few Pc-G) genes are also modifiers of PEV. Together, these data establish a model in which the modulation of chromatin domains is mechanistically linked with the regulation of key developmental loci (e.g. HOM-C).
引用
收藏
页码:80 / 93
页数:14
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