Future generations of red blood cell substitutes

被引：73

作者：

Chang, TMS ^{[1
]}

机构：

[1] McGill Univ, Fac Med, Artificial Cells & Organs Res Ctr, Montreal, PQ H3G 1Y6, Canada

来源：

JOURNAL OF INTERNAL MEDICINE | 2003年 / 253卷 / 05期

关键词：

antioxidant; artificial red blood cells; blood substitutes; microencapsulation; nanoencapsulation; oxygen carriers;

D O I：

10.1046/j.1365-2796.2003.01151.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polyhaemoglobins (PolyHb) and perfluorochemicals are in advanced phase III clinical trials and conjugated haemoglobins in phase II clinical trial. New recombinant human haemoglobin with no vasoactivity is being developed. A soluble macromolecule of PolyHb-catalase-superoxide dismutase is being studied as an oxygen carrier with antioxidant properties. New artificial red blood cells that are more like RBC are being developed. One is based on haemoglobin lipid vesicles. A more recent one is based on nano-dimension artificial red blood cells containing haemoglobin and RBC enzymes with membrane formed from composite copolymer of polyethylene glycol-polylactic acid. Their circulation time is double that of PolyHb.

引用

页码：527 / 535

页数：9

共 52 条

[1] Adamson JG, 1998, TISS ENG, P62
[2] Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?
Alayash, AI
[J]. NATURE BIOTECHNOLOGY, 1999, 17 (06) : 545 - 549
[3] [Anonymous], ARTIFICIAL CELLS BLO
[4] BINGLAN Y, 2002, P CAN FED BIOL SOC 4, P76
[5] Resuscitative effects of polynitroxylated αα-cross-linked hemoglobin following severe hemorrhage in the rat
Buehler, PW
Mehendale, S
Wang, HS
Xie, JT
Ma, L
Trimble, CE
Hsia, CJC
Gulati, A
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (08) : 764 - 774
[6] Bunn H F, 1968, Trans Assoc Am Physicians, V81, P147
[7] Carmichael FJL, 2001, TRANSFUS APHER SCI, V24, P17
[8] Chang T., 1997, US Pat, Patent No. 5670173
[9] Chang Thomas M S, 2002, Curr Opin Investig Drugs, V3, P1187
[10] SEMIPERMEABLE MICROCAPSULES CONTAINING CATALASE FOR ENZYME REPLACEMENT IN ACATALASAEMIC MICE
CHANG, TMS
POZNANSKY, MJ
[J]. NATURE, 1968, 218 (5138) : 243 - +

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