Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata

被引：71

作者：

Kam, TS ^{[1
]}

Pang, HS

Choo, YM

Komiyama, K

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Kitasato Inst, Minato Ku, Tokyo 108, Japan

来源：

CHEMISTRY & BIODIVERSITY | 2004年 / 1卷 / 04期

关键词：

D O I：

10.1002/cbdv.200490056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Six new indole alkaloids, viz., (3S)-3-cyanocoronaridine (2), (3S)-3-cyanoisovoacangine (3), conolobine A (5), conolobine B (6), conolidine (7), and (3R/3S)-3-ethoxyvoacangine (8), in addition to 36 known ones, were obtained from the stem-bark extract of the Malayan Tabernaemontana divaricata. The structures were determined by NMR and MS analysis. The CN-substituted alkaloids showed appreciable cytotoxicity towards the KB human oral epidermoid carcinoma cell-line.

引用

页码：646 / 656

页数：11

共 40 条

[1]

CONSTITUENTS OF WEST-AFRICAN MEDICINAL-PLANTS .3. 19-ETHOXYCORONARIDINE, A NOVEL ALKALOID FROM TABERNAEMONTANA-GLANDULOSA [J].