The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: A brief review

被引:86
作者
Potten, CS [1 ]
Booth, C [1 ]
机构
[1] Christie Hosp NHS Trust, Paterson Inst Canc Res, CRC, Dept Epithelial Biol, Manchester M20 4BX, Lancs, England
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1997年 / 118卷 / 03期
关键词
apoptosis; intestine; epithelium; stem cells; irradiation; p53; bcl-2;
D O I
10.1016/S0305-0491(97)00219-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Until fairly recently, investigations into the control of cell production (proliferation) have been the mainstay of studies into the maintenance of mucosal homeostasis and general integrity. However, in addition to proliferation, it is now increasingly evident that programmed cell death, specifically that form of programmed cell death known as apoptosis, is an equally, if not more important, mechanism of regulating mucosal cell number. This review will concentrate on the significance of damage (radiation) induced and spontaneous apoptosis in the maintenance of intestinal epithelial stem cell number and integrity, and its probable link to the level of cancer incidence in the small intestine and colon. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:473 / 478
页数:6
相关论文
共 18 条
[1]  
HAGUE A, 1994, ONCOGENE, V9, P3367
[2]   CELL-DEATH (APOPTOSIS) IN THE MOUSE SMALL-INTESTINE AFTER LOW-DOSES - EFFECTS OF DOSE-RATE, 14.7 MEV NEUTRONS, AND 600 MEV (MAXIMUM ENERGY) NEUTRONS [J].
HENDRY, JH ;
POTTEN, CS ;
CHADWICK, C ;
BIANCHI, M .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1982, 42 (06) :611-620
[3]   BCL2 PROTEIN IS TOPOGRAPHICALLY RESTRICTED IN TISSUES CHARACTERIZED BY APOPTOTIC CELL-DEATH [J].
HOCKENBERY, DM ;
ZUTTER, M ;
HICKEY, W ;
NAHM, M ;
KORSMEYER, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :6961-6965
[4]  
Ijiri K., 1987, P326
[5]   CANCER - P53, GUARDIAN OF THE GENOME [J].
LANE, DP .
NATURE, 1992, 358 (6381) :15-16
[6]  
LI YQ, 1994, J CELL SCI, V107, P3271
[7]  
MERRITT AJ, 1995, J CELL SCI, V108, P2261
[8]  
MERRITT AJ, 1994, CANCER RES, V54, P614
[9]  
Potten C, 1983, STEM CELLS THEIR IDE, V155-99
[10]  
Potten C, 1983, CYTOTOXIC INSULT TIS, V105-52