Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes

被引:107
作者
Withers, DJ
White, M
机构
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Howard Hughes Med Inst, Boston, MA 02215 USA
[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Metab Med, London W12 0NN, England
关键词
D O I
10.1210/en.141.6.1917
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1917 / 1921
页数:5
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共 23 条
  • [1] MOLECULAR DEFECTS OF THE INSULIN-RECEPTOR GENE
    ACCILI, D
    [J]. DIABETES-METABOLISM REVIEWS, 1995, 11 (01): : 47 - 62
  • [2] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    Accili, D
    Drago, J
    Lee, EJ
    Johnson, MD
    Cool, MH
    Salvatore, P
    Asico, LD
    Jose, PA
    Taylor, SI
    Westphal, H
    [J]. NATURE GENETICS, 1996, 12 (01) : 106 - 109
  • [3] Mechanism of activation and function of protein kinase B
    Alessi, DR
    Cohen, P
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (01) : 55 - 62
  • [4] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE
    ARAKI, E
    LIPES, MA
    PATTI, ME
    BRUNING, JC
    HAAG, B
    JOHNSON, RS
    KAHN, CR
    [J]. NATURE, 1994, 372 (6502) : 186 - 190
  • [5] Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
    Brunet, A
    Bonni, A
    Zigmond, MJ
    Lin, MZ
    Juo, P
    Hu, LS
    Anderson, MJ
    Arden, KC
    Blenis, J
    Greenberg, ME
    [J]. CELL, 1999, 96 (06) : 857 - 868
  • [6] A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    Bruning, JC
    Michael, MD
    Winnay, JN
    Hayashi, T
    Horsch, D
    Accili, D
    Goodyear, LJ
    Kahn, CR
    [J]. MOLECULAR CELL, 1998, 2 (05) : 559 - 569
  • [7] Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    Cline, GW
    Petersen, KF
    Krssak, M
    Shen, J
    Hundal, RS
    Trajanoski, Z
    Inzucchi, S
    Dresner, A
    Rothman, DL
    Shulman, GI
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) : 240 - 246
  • [8] Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    Kido, Y
    Burks, DJ
    Withers, D
    Bruning, JC
    Kahn, CR
    White, MF
    Accili, D
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (02) : 199 - 205
  • [9] daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    Kimura, KD
    Tissenbaum, HA
    Liu, YX
    Ruvkun, G
    [J]. SCIENCE, 1997, 277 (5328) : 942 - 946
  • [10] Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
    Kulkarni, RN
    Brüning, JC
    Winnay, JN
    Postic, C
    Magnuson, MA
    Kahn, CR
    [J]. CELL, 1999, 96 (03) : 329 - 339