Dose-related anti-inflammatory/analgesic effects of lornoxicam: A spinal c-Fos protein study in the rat

被引:25
作者
Buritova, J
Besson, JM
机构
[1] INSERM, U161, Unite Rech Physiopharmacol Syst Nerveux, F-75014 Paris, France
[2] EPHE, F-75014 Paris, France
关键词
carrageenan; c-Fos; dorsal horn; lornoxicam; nociception;
D O I
10.1007/s000110050245
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective: To evaluate the anti-inflammatory/analgesic effects of lornoxicam in the carrageenan model of inflammatory nociception. Material and Methods: Three hours after intraplantar carrageenan (6 mg/150 mu l of saline), we assessed the effects of pre-administered lornoxicam (0.1, 0.3, 1, 3 and 9 mg/kg i.v., n=10 rats for each group) on both the peripheral oedema and number of c-Fos-protein-like immunoreactive (c-Fos-LI) neurons in the lumbar L4-L5 segments. in the awake rat. Results: Lornoxcam dose-relatedly reduced both the carrageenan evoked oedema (r=0.63 and r=0.53 for paw and ankle diameter respectively: p<0.001 for both) and total number of spinal c-Fos-LI neurons (r=0.79, p<0.001), with the strongest effect corresponding to a 75 +/- 2% reduction of the number of f-Fos-LI neurons (p<0.001) for the highest dose (9 mg/kg), and a 45 +/- 3% reduction (p<0.001) for the low dose of 0.3 mg/kg. Reductions of both rile peripheral oedema and spinal c-Fos expression were correlated (r=0.74 and r=0.57 for the paw and ankle diameter respectively: p<0.001 for both). Conclusions: Our results demonstrate that lornoxicam reduces in parallel both the carrageenan-evoked oedema and spinal c-Fos expression, with clear evidence for a potent effect of low doses of lornoxicam. Correlated reductions in c-Fos expression and paw oedema suggest a predominantly peripheral site of action of lornoxicam.
引用
收藏
页码:18 / 25
页数:8
相关论文
共 61 条
[1]   INTENSE COLD NOXIOUS-STIMULATION OF THE RAT HINDPAW INDUCES C-FOS EXPRESSION IN LUMBAR SPINAL-CORD NEURONS [J].
ABBADIE, C ;
HONORE, P ;
BESSON, JM .
NEUROSCIENCE, 1994, 59 (02) :457-468
[2]   EFFECTS OF OPIOIDS AND NON-OPIOIDS ON C-FOS-LIKE IMMUNOREACTIVITY INDUCED IN RAT LUMBAR SPINAL-CORD NEURONS BY NOXIOUS HEAT STIMULATION [J].
ABBADIE, C ;
HONORE, P ;
FOURNIEZALUSKI, MC ;
ROQUES, BP ;
BESSON, JM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 258 (03) :215-227
[3]   EFFECTS OF MORPHINE AND NALOXONE ON BASAL AND EVOKED FOS-LIKE IMMUNOREACTIVITY IN LUMBAR SPINAL-CORD NEURONS OF ARTHRITIC RATS [J].
ABBADIE, C ;
BESSON, JM .
PAIN, 1993, 52 (01) :29-39
[4]  
Abbadie C, 1994, NATO ADV SCI INST SE, V79, P449
[5]   CHRONIC TREATMENTS WITH ASPIRIN OR ACETAMINOPHEN REDUCE BOTH THE DEVELOPMENT OF POLYARTHRITIS AND FOS-LIKE IMMUNOREACTIVITY IN RAT LUMBAR SPINAL-CORD [J].
ABBADIE, C ;
BESSON, JM .
PAIN, 1994, 57 (01) :45-54
[6]   REPORTED ADVERSE DRUG-REACTIONS AND CONSUMPTION OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].
ALHAVA, E .
PHARMACOLOGY & TOXICOLOGY, 1994, 75 :37-43
[7]   Lornoxicam - A review of its pharmacology and therapeutic potential in the management of painful and inflammatory conditions [J].
Balfour, JA ;
Fitton, A ;
Barradell, LB .
DRUGS, 1996, 51 (04) :639-657
[8]   A DOUBLE-BLIND, MULTICENTER, PLACEBO CONTROLLED TRIAL OF LORNOXICAM IN PATIENTS WITH OSTEOARTHRITIS OF THE HIP AND KNEE [J].
BERRY, H ;
BIRD, HA ;
BLACK, C ;
BLAKE, DR ;
FREEMAN, AM ;
GOLDING, DN ;
HAMILTON, EBD ;
JAYSON, MIV ;
KIDD, B ;
KOHN, H ;
MILLION, R ;
OLLIER, S ;
SMITH, I ;
WILLIAMS, BD ;
WOOLF, AD .
ANNALS OF THE RHEUMATIC DISEASES, 1992, 51 (02) :238-242
[9]   PERIPHERAL AND SPINAL MECHANISMS OF NOCICEPTION [J].
BESSON, JM ;
CHAOUCH, A .
PHYSIOLOGICAL REVIEWS, 1987, 67 (01) :67-186
[10]   Interactions between NMDA- and prostaglandin receptor-mediated events in a model of inflammatory nociception [J].
Buritova, J ;
Chapman, V ;
Honore, P ;
Besson, JM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 303 (1-2) :91-100