Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycle

被引：37

作者：

Chatterjee, Indranil

Herrmann, Mathias

Proctor, Richard A.

Peters, Georg

Kahl, Barbara C.

机构：

[1] Univ Saarland, Inst Med Microbiol & Hyg, Inst Infect Dis Med, D-66421 Homburg, Germany

[2] Univ Wisconsin, Sch Med, Dept Med, Madison, WI USA

[3] Univ Wisconsin, Sch Med, Dept Med Microbiol & Immunol, Madison, WI USA

[4] Univ Hosp Munster, Inst Med Microbiol, Munster, Germany

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 07期

关键词：

GENE-EXPRESSION; RECURRENT INFECTIONS; CYSTIC-FIBROSIS; PERSISTENT; GROWTH; REGULATOR; PATHOGEN; RECOVERY; ACETATE; MUTANT;

D O I：

10.1128/JB.01444-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

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收藏

页码：2936 / 2940

页数：5

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