Identification of target organs of copper nanoparticles with ICP-MS technique

被引：41

作者：

Chen, Zhen ^{[1
]}

Meng, Huan

Yuan, Hui

Xing, Gengmei

Chen, Chunying

Zhao, Feng

Wang, Yun

Zhang, Chengcheng

Zhao, Yuliang

机构：

[1] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China

[2] Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Natl Ctr Nanosci & Nanotechnol, Beijing 100081, Peoples R China

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2007年 / 272卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1007/s10967-007-0631-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.

引用

收藏

页码：599 / 603

页数：5

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