DNA damage induced by peroxynitrite: Subsequent biological effects

被引：379

作者：

Szabo, C

Ohshima, H

机构：

[1] Childrens Hosp, Med Ctr, Div Crit Care, Cincinnati, OH 45229 USA

[2] Int Agcy Res Canc, Unit Endogenous Canc Risk Factors, F-69372 Lyon 08, France

来源：

NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 1997年 / 1卷 / 05期

关键词：

free radical; peroxynitrite; nitric oxide; superoxide; 8-nitroguanine; 8-oxoguanine; DNA strand break; apoptosis; poly(ADP-ribose) synthetase; septic shock; endotoxin; inflammation; stroke; diabetes; cancer;

D O I：

10.1006/niox.1997.0143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite, Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis. (C) 1997 Academic Press.

引用

收藏

页码：373 / 385

页数：13

相关论文

共 107 条

[1] CONSTITUTIVE AND INDUCIBLE NITRIC-OXIDE SYNTHASE GENE-EXPRESSION, REGULATION, AND ACTIVITY IN HUMAN LUNG EPITHELIAL-CELLS [J].

ASANO, K ;

CHEE, CBE ;

GASTON, B ;

LILLY, CM ;

GERARD, C ;

DRAZEN, JM ;

STAMLER, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :10089-10093

[2] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].

BECKMAN, JS ;

BECKMAN, TW ;

CHEN, J ;

MARSHALL, PA ;

FREEMAN, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624

[3]

Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424

[4] KINETICS OF SUPEROXIDE DISMUTASE-CATALYZED AND IRON-CATALYZED NITRATION OF PHENOLICS BY PEROXYNITRITE [J].

BECKMAN, JS ;

ISCHIROPOULOS, H ;

ZHU, L ;

VANDERWOERD, M ;

SMITH, C ;

CHEN, J ;

HARRISON, J ;

MARTIN, JC ;

TSAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) :438-445

[5] HEAT-SHOCK INDUCES RESISTANCE IN RAT PANCREATIC-ISLET CELLS AGAINST NITRIC-OXIDE, OXYGEN RADICALS AND STREPTOZOTOCIN TOXICITY IN-VITRO [J].

BELLMANN, K ;

WENZ, A ;

RADONS, J ;

BURKART, V ;

KLEEMANN, R ;

KOLB, H .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (06) :2840-2845

[6]

BERGER NA, 1991, AM J RESP CELL MOL, V4, P1

[7] METABOLIC CONSEQUENCES OF DNA DAMAGE - DNA DAMAGE INDUCED ALTERATIONS IN GLUCOSE-METABOLISM BY ACTIVATION OF POLY(ADP-RIBOSE) POLYMERASE [J].

BERGER, SJ ;

SUDAR, DC ;

BERGER, NA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 134 (01) :227-232

[8] APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES [J].

BONFOCO, E ;

KRAINC, D ;

ANKARCRONA, M ;

NICOTERA, P ;

LIPTON, SA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7162-7166

[9]

BURGER RM, 1994, J BIOL CHEM, V269, P25978

[10] A mechanistic analysis of nitric oxide-induced cellular toxicity [J].

Burney, S ;

Tamir, S ;

Gal, A ;

Tannenbaum, SR .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 1997, 1 (02) :130-144

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