A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

被引：61

作者：

Andres, Allen M. ^{[1
]}

Stotland, Aleksandr ^{[1
]}

Queliconi, Bruno B. ^{[1
]}

Gottlieb, Roberta A. ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 78卷

关键词：

Mitochondria; Autophagy; Mitophagy; Mitochondrial biogenesis; Cardiac; Pathogenesis; PROMOTES MITOCHONDRIAL BIOGENESIS; CIRCADIAN AUTOPHAGY RHYTHM; SKELETAL-MUSCLE; MITOFUSIN; MYOCARDIAL-ISCHEMIA; DIURNAL-VARIATIONS; ISCHEMIA/REPERFUSION INJURY; DOXORUBICIN CARDIOTOXICITY; PGC-1-ALPHA TRANSCRIPTION; ENERGY-EXPENDITURE;

D O I：

10.1016/j.yjmcc.2014.10.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease". (C) 2014 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.

引用

页码：62 / 72

页数：11

共 182 条

[1]

Exercise stimulates Pgc-1α transcription in skeletal muscle through activation of the p38 MAPK pathway [J].