Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

被引：491

作者：

Zhang, Hao ^{[1
]}

Wei, Jing ^{[2
]}

Xue, Rong ^{[3
]}

Wu, Jin-Dan ^{[2
]}

Zhao, Wei ^{[3
]}

Wang, Zi-Zheng ^{[2
]}

Wang, Shu-Kui ^{[2
]}

Zhou, Zheng-Xian ^{[3
]}

Song, Dan-Qing ^{[1
]}

Wang, Yue-Ming ^{[1
]}

Pan, Huai-Ning ^{[2
]}

Kong, Wei-Jia ^{[1
]}

Jiang, Jian-Dong ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Dept Pharmacol, Beijing 100050, Peoples R China

[2] Nanjing First Hosp, Dept Med, Nanjing 210006, Peoples R China

[3] Nanjing Second Hosp, Dept Med, Nanjing 210003, Peoples R China

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2010年 / 59卷 / 02期

关键词：

ACTIVATED PROTEIN-KINASE; RESISTANCE; PATHOGENESIS; MECHANISM; GENE; HEPATOTOXICITY; DEFICIENCY; METFORMIN; THERAPY; COMPLEX;

D O I：

10.1016/j.metabol.2009.07.029

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Our previous work demonstrated that berberine (BBR) increases insulin receptor (InsR) expression and improves glucose utility both in vitro and in animal models Here, we study the InsR up-regulating and glucose-lowering activities of BBR in humans Our results showed that BBR increased InsR messenger RNA and protein expression in a variety of human cell lines, including CEM, HCT-116, SW1990, HT1080, 293T, and hepatitis B virus-transfected human liver cells Accordingly, insulin-stimulated phosphorylanons of InsR beta-subunit and Akt were increased after BBR treatment in cultured cells In the clinical study, BBR significantly lowered fasting blood glucose (FBG), hemoglobin Ate, triglyceride, and insulin levels in patients with type 2 diabetes mellitus (T2DM) The FBG- and hemoglobin A(tc)- lowering efficacies of BBR were similar to those of metformin and rosiglitazone In the BBR-treated patients, the percentages of peripheral blood lymphocytes that express InsR were significantly elevated after therapy Berberine also lowered FBG effectively in chronic hepatitis B and hepatitis C patients with T2DM ot impaired fasting glucose Liver function was improved greatly in these patients by showing reduction of liver enzymes Our results confirmed the activity of BBR on InsR in humans and its relationship with the glucose-lowering effect Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone (C) 2010 Elsevier Inc All rights reserved

引用

页码：285 / 292

页数：8

共 40 条

[1]

Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine [J].

Abidi, P ;

Zhou, Y ;

Jiang, JD ;

Liu, JW .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (10) :2170-2176

[2]

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity [J].

Air, EL ;

Strowski, MZ ;

Benoit, SC ;

Conarello, SL ;

Salituro, GM ;

Guan, XM ;

Liu, K ;

Woods, SC ;

Zhang, BB .

NATURE MEDICINE, 2002, 8 (02) :179-183

[3]

[Anonymous], 1955, CHINESE J MED GENET

[4]

Hepatotoxicity of commonly used drugs: Nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs [J].

Chitturi, S ;

George, J .

SEMINARS IN LIVER DISEASE, 2002, 22 (02) :169-183

[5]

Contraindications to metformin therapy in patients with Type 2 diabetes - a population-based study of adherence to prescribing guidelines [J].

Emslie-Smith, AM ;

Boyle, DIR ;

Evans, JMM ;

Sullivan, F ;

Morris, AD .

DIABETIC MEDICINE, 2001, 18 (06) :483-488

[6]

Ferrannini E, 1998, ENDOCR REV, V19, P477, DOI 10.1210/er.19.4.477

[7]

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice [J].

Foti, D ;

Chiefari, E ;

Fedele, M ;

Iuliano, R ;

Brunetti, L ;

Paonessa, F ;

Manfioletti, G ;

Barbetti, F ;

Brunetti, A ;

Croce, CM ;

Fusco, A ;

Brunetti, A .

NATURE MEDICINE, 2005, 11 (07) :765-773

[8]

A nucleoprotein complex containing sp1, C/EBPβ, and HMGI-Y controls human insulin receptor gene transcription [J].

Foti, D ;

Iuliano, R ;

Chiefari, E ;

Brunetti, A .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (08) :2720-2732

[9]

Insulin sensitivity in subjects with type 2 diabetes - Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study [J].

Haffner, SM ;

D'Agostino, R ;

Mykkanen, L ;

Tracy, R ;

Howard, B ;

Rewers, M ;

Selby, J ;

Savage, PJ ;

Saad, MF .

DIABETES CARE, 1999, 22 (04) :562-568

[10]

HOMOZYGOSITY FOR A NEW MUTATION (ILE(119)-]MET) IN THE INSULIN-RECEPTOR GENE IN 5 SIBS WITH FAMILIAL INSULIN-RESISTANCE [J].

HONE, J ;

ACCILI, D ;

ALGAZALI, LI ;

LESTRINGANT, G ;

ORBAN, T ;

TAYLOR, SI .

JOURNAL OF MEDICAL GENETICS, 1994, 31 (09) :715-716

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