A new principle in combinatorial asymmetric transition-metal catalysis: Mixtures of chiral monodentate P ligands

被引：225

作者：

Reetz, MT ^{[1
]}

Sell, T ^{[1
]}

Meiswinkel, A ^{[1
]}

Mehler, G ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 07期

关键词：

asymmetric catalysis; combinatorial chemistry; hydrogenation; phosphorus; rhodium;

D O I：

10.1002/anie.200390209

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The right mix!: Surprisingly, the use of the mixture of two different chiral monodentate phosphorus ligands (e.g., a phosphonite/phosphite combination; see schematic representation; cod=1,5-cyclooctadiene) in Rh-catalyzed olefin hydrogenation leads to significantly higher enantioselectivities than in the case of the pure ligands themselves.

引用

页码：790 / 793

页数：4

共 48 条

[1] Combinatorial de Novo synthesis of catalysts: How much of a hit-structure is needed for activity?
Berkessel, A
Riedl, R
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (03): : 215 - 219
[2] New catalysts and conditions for a C-H insertion reaction identified by high throughput catalyst screening
Burgess, K
Lim, HJ
Porte, AM
Sulikowski, GA
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (02): : 220 - 222
[3] Burgess K., 1996, ANGEW CHEM, V108, P192
[4] A three-step procedure for asymmetric catalytic reductive amidation of ketones
Burk, MJ
Casy, G
Johnson, NB
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (18) : 6084 - 6085
[5] Claver C, 2000, CHEM COMMUN, P961
[6] Dahmen S, 2001, SYNTHESIS-STUTTGART, P1431
[7] Francis M. B., 1999, ANGEW CHEM, V111, P987
[8] Francis MB, 1999, ANGEW CHEM INT EDIT, V38, P937, DOI 10.1002/(SICI)1521-3773(19990401)38:7<937::AID-ANIE937>3.0.CO
[9] 2-O
[10] Investigation of a new family of chiral ligands for enantioselective catalysis via parallel synthesis and high-throughput screening
Gennari, C
Ceccarelli, S
Piarulli, U
Montalbetti, CAGN
Jackson, RFW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (16) : 5312 - 5313

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