Immunosenescence and germinal center reaction

被引:162
作者
Zheng, B [1 ]
Han, SH [1 ]
Takahashi, Y [1 ]
Kelsoe, G [1 ]
机构
[1] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA
关键词
D O I
10.1111/j.1600-065X.1997.tb01028.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self-reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged. While this reduction is likely the result of age-associated impairment in lymphocyte function (e.g. diminished response to costimulus, altered lymphokine production etc.), the reduction of germinal centers may itself make an important contribution to further immunological dysfunction.
引用
收藏
页码:63 / 77
页数:15
相关论文
共 179 条
[1]   ANTIBODY ENGINEERING FOR THE ANALYSIS OF AFFINITY MATURATION OF AN ANTI-HAPTEN RESPONSE [J].
ALLEN, D ;
SIMON, T ;
SABLITZKY, F ;
RAJEWSKY, K ;
CUMANO, A .
EMBO JOURNAL, 1988, 7 (07) :1995-2001
[2]   CD40 LIGAND GENE DEFECTS RESPONSIBLE FOR X-LINKED HYPER-IGM SYNDROME [J].
ALLEN, RC ;
ARMITAGE, RJ ;
CONLEY, ME ;
ROSENBLATT, H ;
JENKINS, NA ;
COPELAND, NG ;
BEDELL, MA ;
EDELHOFF, S ;
DISTECHE, CM ;
SIMONEAUX, DK ;
FANSLOW, WC ;
BELMONT, J ;
SPRIGGS, MK .
SCIENCE, 1993, 259 (5097) :990-993
[3]   MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].
ARMITAGE, RJ ;
FANSLOW, WC ;
STROCKBINE, L ;
SATO, TA ;
CLIFFORD, KN ;
MACDUFF, BM ;
ANDERSON, DM ;
GIMPEL, SD ;
DAVISSMITH, T ;
MALISZEWSKI, CR ;
CLARK, EA ;
SMITH, CA ;
GRABSTEIN, KH ;
COSMAN, D ;
SPRIGGS, MK .
NATURE, 1992, 357 (6373) :80-82
[4]   GENERATION OF MEMORY B-CELLS AND PLASMA-CELLS IN-VITRO [J].
ARPIN, C ;
DECHANET, J ;
VANKOOTEN, C ;
MERVILLE, P ;
GROUARD, G ;
BRIERE, F ;
BANCHEREAU, J ;
LIU, YJ .
SCIENCE, 1995, 268 (5211) :720-722
[5]   B70 ANTIGEN IS A 2ND LIGAND FOR CTLA-4 AND CD28 [J].
AZUMA, M ;
ITO, D ;
YAGITA, H ;
OKUMURA, K ;
PHILLIPS, JH ;
LANIER, LL ;
SOMOZA, C .
NATURE, 1993, 366 (6450) :76-79
[6]   The role of antibody concentration and avidity in antiviral protection [J].
Bachmann, MF ;
Kalinke, U ;
Althage, A ;
Freer, G ;
Burkhart, C ;
Roost, HP ;
Aguet, M ;
Hengartner, H ;
Zinkernagel, RM .
SCIENCE, 1997, 276 (5321) :2024-2027
[7]   GROWING HUMAN LYMPHOCYTES-B IN THE CD40 SYSTEM [J].
BANCHEREAU, J ;
ROUSSET, F .
NATURE, 1991, 353 (6345) :678-679
[8]  
BANKS TA, 1995, J IMMUNOL, V155, P1685
[9]   CRYSTAL-STRUCTURE OF THE SOLUBLE HUMAN 55 KD TNF RECEPTOR-HUMAN TNF-BETA COMPLEX - IMPLICATIONS FOR TNF RECEPTOR ACTIVATION [J].
BANNER, DW ;
DARCY, A ;
JANES, W ;
GENTZ, R ;
SCHOENFELD, HJ ;
BROGER, C ;
LOETSCHER, H ;
LESSLAUER, W .
CELL, 1993, 73 (03) :431-445
[10]  
BENNER R, 1974, IMMUNOLOGY, V26, P247