Involvement of H2O2 production in cisplatin-induced nephrotoxicity

被引：46

作者：

Tsutsumishita, Y

Onda, T

Okada, K

Takeda, M

Endou, H

Futaki, S

Niwa, M ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 770, Japan

[2] Komatsushima Red Cross Hosp, Tokushima 773, Japan

[3] Kyorin Univ, Dept Pharmacol & Toxicol, Sch Med, Tokyo 181, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 242卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7962

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this study was to elucidate the involvement of H2O2 production in cisplatin-induced nephrotoxicity. The S-3 cells were more sensitive than OMCT cells iu cell viability and H2O2 production during cisplatin treatment, The cytotoxicity and H2O2 production induced by cisplatin were terminated by treatment with catalase, In conclusion, we emphasize the importance of the hydroxy radical in cisplatin nephrotoxicity. (C) 1998 Academic Press.

引用

页码：310 / 312

页数：3

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