Artificial protein sensors

被引：25

作者：

Schrader, Thomas ^{[1
]}

Koch, Sebastian ^{[1
]}

机构：

[1] Univ Essen Gesamthsch, Dept Chem, D-45117 Essen, Germany

来源：

MOLECULAR BIOSYSTEMS | 2007年 / 3卷 / 04期

关键词：

D O I：

10.1039/b614103j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein recognition by synthetic molecules is a challenging endeavour, since these materials must bind to a large relatively flat surface domain and recognize a unique distribution of amino acid residues of varying charge, size and shape. The most promising routes involve specific metal coordination, epitope-clocking on miniature proteins, aptamer selection, nonnatural pepticle isosteres, functionalized platforms, secondary structure mimetics, molecular imprinting and receptors embedded in lipid layers.

引用

页码：241 / 248

页数：8

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