1-Deoxy-D-xylulose 5-phosphate reductoisomerase: an overview

被引：88

作者：

Proteau, PJ ^{[1
]}

机构：

[1] Oregon State Univ, Coll Pharm, Dept Pharmaceut Sci, Corvallis, OR 97331 USA

来源：

BIOORGANIC CHEMISTRY | 2004年 / 32卷 / 06期

关键词：

deoxyxylulose 5-phosphate reductoisomerase; methylerythritol; 4-phosphate; MEP pathway; isoprenoids; non-mevalonate pathway; MEP synthase; isomeroreductase;

D O I：

10.1016/j.bioorg.2004.08.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The methylerythritol phosphate pathway to isoprenoids, an alternate biosynthetic route present in many bacteria, algae, plants, and the malarial parasite Plasmodium falciparum, has become an attractive target for the development of new antimalarial and antibacterial compounds. The second enzyme in this pathway, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR; EC 1.1.1.267), has been shown to be the molecular target for fosmidomycin, a promising antimalarial drug. This enzyme converts 1-deoxy-D-xylulose 5-phosphate (DXP) into the branched compound 2-C-methyl-D-erythritol 4-phosphate (MEP). The transformation of DXP into MEP requires an isomerization, followed by a NADPH-dependent reduction. The discovery of DXR, its subsequent characterization, and the identification of inhibitors will be presented. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：483 / 493

页数：11

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