ALK-positive diffuse large B-cell lymphoma of the stomach associated with a clathirin-ALK rearrangement

被引：31

作者：

McManus, DT

Catherwood, MA

Carey, PD

Cuthbert, RJG

Alexander, HD

机构：

[1] Belfast City Hosp, Dept Histopathol, The Labs, Belfast BT9 7AD, Antrim, North Ireland

[2] Belfast City Hosp, Dept Tissue Pathol, Belfast BT9 7AD, Antrim, North Ireland

[3] Belfast City Hosp, Dept Haematol, Belfast BT9 7AD, Antrim, North Ireland

来源：

HUMAN PATHOLOGY | 2004年 / 35卷 / 10期

关键词：

stomach; ALK; diffuse large B-cell lymphoma; t(2,17); clathrin-ALK rearrangements;

D O I：

10.1016/j.humpath.2004.06.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

ALK-positive diffuse large B-cell lymphoma is a rare, recently characterized lymphoma subtype that shows granular cytoplasmic ALK expression. This report describes a primary gastric ALK-positive B-lineage lymphoma in which a clathrin (CLTC)-ALK fusion was identified by RT-PCR and direct sequencing of the breakpoint. This confirmed the presence of t(2;17) (p23;q23) involving the CLTC gene and is only the 4th report of such a translocation in this lymphoma subtype and the first to describe this tumor within the stomach. As in previous reports, immunophenotyping showed the malignant cell to be a terminally differentiated B-lineage cell characterized by the absence of B-cell antigens and expression of antigens associated with plasma cell differentiation. This case confirms the existence of such a lymphoma subtype arising in extranodal locations and underscores the importance of detailed immunophenotyping and specialized molecular genetic investigations in confirming the diagnosis. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1285 / 1288

页数：4

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