Leukocyte function in the aging immune system

被引：93

作者：

Desai, Anjali ^{[1
,2
]}

Grolleau-Julius, Annabelle ^{[1
,2
]}

Yung, Raymond ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Geriatr Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Internal Med, Div Rheumatol, Ann Arbor, MI 48109 USA

[3] Ann Arbor Vet Affairs Hlth Syst, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 87卷 / 06期

关键词：

dendritic cells; monocytes; macrophages; T cells; T-CELL SUBSETS; PLASMACYTOID DENDRITIC CELLS; AGE-ASSOCIATED DECLINE; NECROSIS-FACTOR-ALPHA; MEMORY B-CELL; PERIPHERAL-BLOOD; OLD-AGE; IN-VIVO; REPLICATIVE SENESCENCE; RHEUMATOID-ARTHRITIS;

D O I：

10.1189/jlb.0809542

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is associated with a progressive dysregulation of immune responses. Whether these changes are solely responsible for the observed increased mortality and morbidity amongst the elderly is uncertain. Recent advances have highlighted the age-associated changes that occur beyond T and B lymphocytes. Additionally, multiple human and animal studies have identified a relationship between chronic low-grade inflammation and geriatric syndromes, such as frailty, suggesting that the phenomenon of "inflamm-aging" may provide a rationale for the increased vulnerability to chronic inflammatory diseases in older adults. In the present review, we broadly summarize our current understanding of age-dependent changes in leukocyte function and their contribution to aging-related disease processes. J. Leukoc. Biol. 87: 1001-1009; 2010.

引用

页码：1001 / 1009

页数：9

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