TGF-β activation by traction?

被引：66

作者：

Keski-Oja, J ^{[1
]}

Koli, K

von Melchner, H

机构：

[1] Univ Helsinki, Haartman Inst, Dept Virol, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland

[3] Univ Helsinki Hosp, FIN-00014 Helsinki, Finland

[4] Univ Frankfurt, Sch Med, Dept Mol Hematol, D-60596 Frankfurt, Germany

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.tcb.2004.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transforming growth factor (TGF)-betas are powerful cytokines that are secreted as inactive (latent) precursors into the extracellular space. To exert their pleiotropic functions, latent TGF-betas require activation. This requisite restricts TGF-beta signaling to tissues that express TGF-beta-activating proteins such as the adhesion molecule alphavbeta6 integrin. Recent work has uncovered the molecular mechanism by which alphavbeta6 integrin activates latent TGF-beta. Latent-TGF-beta-binding protein 1 has been identified as being the major component of this process, and the integrin-interacting region has been mapped to a poorly conserved sequence stretch called the hinge region.

引用

页码：657 / 659

页数：3

共 19 条

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