Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers

被引：21

作者：

Gattringer, R

Urbauer, E

Traunmüller, F

Zeitlinger, M

Dehghanyar, P

Zeleny, P

Graninger, W

Müller, M

Joukhadar, C

机构：

[1] Med Univ Vienna, Dept Clin Pharmacol, Div Clin Pharmacokinet, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Internal Med 1, Div Infect Dis & Chemotherapy, A-1090 Vienna, Austria

[3] Med Univ Vienna, Inst Pharmacol, A-1090 Vienna, Austria

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 12期

关键词：

D O I：

10.1128/AAC.48.12.4650-4653.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.

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页码：4650 / 4653

页数：4

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