Comparative primate genomics

被引:75
作者
Enard, W [1 ]
Pääbo, S [1 ]
机构
[1] Max Planck Inst Evolutionary Anthropol, D-04103 Leipzig, Germany
关键词
chimpanzee; apes; gene expression; molecular evolution; selection;
D O I
10.1146/annurev.genom.5.061903.180040
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
With the completion of the human genome sequence and the advent of technologies to study functional aspects of genomes, molecular comparisons between humans and other primates have gained momentum. The comparison of the human genome to the genomes of species closely related to humans allows the identification of genomic features that set primates apart from other mammals and of features that set certain primates-notably humans-apart from other primates. In this article, we review recent progress in these areas with an emphasis on how comparative approaches may be used to identify functionally relevant features unique to the human genome.
引用
收藏
页码:351 / 378
页数:28
相关论文
共 155 条
[1]   Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence [J].
Anzai, T ;
Shiina, T ;
Kimura, N ;
Yanagiya, K ;
Kohara, S ;
Shigenari, A ;
Yamagata, T ;
Kulski, JK ;
Naruse, TK ;
Fujimori, Y ;
Fukuzumi, Y ;
Yamazaki, M ;
Tashiro, H ;
Iwamoto, C ;
Umehara, Y ;
Imanishi, T ;
Meyer, A ;
Ikeo, K ;
Gojobori, T ;
Bahram, S ;
Inoko, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) :7708-7713
[2]   Molecular estimates of primate divergences and new hypotheses for primate dispersal and the origin of modern humans [J].
Arnason, U ;
Gullberg, A ;
Burguete, AS ;
Janke, A .
HEREDITAS, 2000, 133 (03) :217-228
[3]   Analysis of segmental duplications and genome assembly in the mouse [J].
Bailey, JA ;
Church, DM ;
Ventura, M ;
Rocchi, M ;
Eichler, EE .
GENOME RESEARCH, 2004, 14 (05) :789-801
[4]   An Alu transposition model for the origin and expansion of human segmental duplications [J].
Bailey, JA ;
Liu, G ;
Eichler, EE .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (04) :823-834
[5]   Recent segmental duplications in the human genome [J].
Bailey, JA ;
Gu, ZP ;
Clark, RA ;
Reinert, K ;
Samonte, RV ;
Schwartz, S ;
Adams, MD ;
Myers, EW ;
Li, PW ;
Eichler, EE .
SCIENCE, 2002, 297 (5583) :1003-1007
[6]   Human-specific duplication and mosaic transcripts: The recent paralogous structure of chromosome 22 [J].
Bailey, JA ;
Yavor, AM ;
Viggiano, L ;
Misceo, D ;
Horvath, JE ;
Archidiacono, N ;
Schwartz, S ;
Rocchi, M ;
Eichler, EE .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (01) :83-100
[7]   Segmental duplications: Organization and impact within the current Human Genome Project assembly [J].
Bailey, JA ;
Yavor, AM ;
Massa, HF ;
Trask, BJ ;
Eichler, EE .
GENOME RESEARCH, 2001, 11 (06) :1005-1017
[8]   Alu repeats and human genomic diversity [J].
Batzer, MA ;
Deininger, PL .
NATURE REVIEWS GENETICS, 2002, 3 (05) :370-379
[9]   The Sima de los Huesos hominids date to beyond U/Th equilibrium (>350 kyr) and perhaps to 400-500 kyr:: New radiometric dates [J].
Bischoff, JL ;
Shamp, DD ;
Aramburu, A ;
Arsuaga, JL ;
Carbonell, E ;
de Castro, JMB .
JOURNAL OF ARCHAEOLOGICAL SCIENCE, 2003, 30 (03) :275-280
[10]   Phylogenetic shadowing of primate sequences to find functional regions of the human genome [J].
Boffelli, D ;
McAuliffe, J ;
Ovcharenko, D ;
Lewis, KD ;
Ovcharenko, I ;
Pachter, L ;
Rubin, EM .
SCIENCE, 2003, 299 (5611) :1391-1394