Receptor tyrosine kinases: mechanisms of activation and signaling

被引：369

作者：

Hubbard, Stevan R.

Miller, W. Todd

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA

[3] SUNY Stony Brook, Sch Med, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2007年 / 19卷 / 02期

关键词：

D O I：

10.1016/j.ceb.2007.02.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.

引用

收藏

页码：117 / 123

页数：7

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