Preparation of poly(lactic acid)/chitosan nanoparticles for anti-HIV drug delivery applications

被引：182

作者：

Dev, Ashish ^{[1
,2
]}

Binulal, N. S. ^{[1
,2
]}

Anitha, A. ^{[1
,2
]}

Nair, S. V. ^{[1
,2
]}

Furuike, T. ^{[3
,4
]}

Tamura, H. ^{[3
,4
]}

Jayakumar, R. ^{[1
,2
]}

机构：

[1] Amrita Vishwa Vidhyapeetham Univ, Amrita Ctr Nanosci & Mol Med, Amrita Inst Med Sci, Cochin 682041, Kerala, India

[2] Amrita Vishwa Vidhyapeetham Univ, Res Ctr, Cochin 682041, Kerala, India

[3] Kansai Univ, Fac Chem Mat & Bioengn, Osaka 5648680, Japan

[4] Kansai Univ, High Technol Res Ctr, Osaka 5648680, Japan

来源：

CARBOHYDRATE POLYMERS | 2010年 / 80卷 / 03期

关键词：

Poly(lactic acid); Chitosan; Lamivudine drug; Emulsion; Nanoparticles; Controlled drug delivery; CHITOSAN; DEGRADATION; MICROSPHERES; SCAFFOLDS; BEHAVIOR; RELEASE;

D O I：

10.1016/j.carbpol.2009.12.040

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Poly(lactic acid) (PLA)/chitosan (CS) nanoparticles were prepared by emulsion method for anti-HIV drug delivery applications. The prepared PLA/CS nanoparticles were characterized using DLS, SEM, and FTIR. The hydrophilic antiretroviral drug Lamivudine was loaded into PLA/CS nanoparticles. The encapsulation efficiency and in-vitro drug release behaviour of drug loaded PLA/CS nanoparticles were studied using UV spectrophotometer. In addition, the cytotoxicity of the PLA/CS nanoparticles using MTT assay was also studied. The in-vitro drug release studies showed that drug release rate was lower in the acidic pH when compared to alkaline pH. This may due to repulsion between H ions and cationic groups present in the polymeric nanoparticles. Drug release rate was found to be higher in the 6% drug loaded formulation when compared to 6% drug loaded formulation. These results indicated that the PLA/CS nanoparticles are a promising carrier system for controlled delivery of anti-HIV drugs. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：833 / 838

页数：6

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