Synthesis of a High-Purity Chemical Library Reveals a Potent Inducer of Oxidative Stress

被引：3

作者：

Cui, Jiayue ^{[1
]}

Matsumoto, Kenji ^{[1
]}

Wang, Cindy Y. ^{[2
]}

Peter, Marcus E. ^{[2
]}

Kozmin, Sergey A. ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

[2] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 09期

关键词：

apoptosis; caspases; chemical libraries; cytotoxicity; reactive oxygen species; CELL-DEATH; APOPTOSIS;

D O I：

10.1002/cbic.201000193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

(Chemical Equation Presented) Needle in a haystack: Synthesis of a high-purity, biogenic, heterocyclic, 936-member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused cell death by activating both caspase-dependent and -independent pathways. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1224 / 1227

页数：4

共 17 条

[1]

INDUCTION OF A COMMON PATHWAY OF APOPTOSIS BY STAUROSPORINE [J].