A novel series of 4-phenoxyquinolines: Potent and highly selective inhibitors of PDGF receptor autophosphorylation

被引：24

作者：

Kubo, K ^{[1
]}

Shimizu, T ^{[1
]}

Ohyama, S ^{[1
]}

Murooka, H ^{[1
]}

Nishitoba, T ^{[1
]}

Kato, S ^{[1
]}

Kobayashi, Y ^{[1
]}

Yagi, M ^{[1
]}

Isoe, T ^{[1
]}

Nakamura, K ^{[1
]}

Osawa, T ^{[1
]}

Izawa, T ^{[1
]}

机构：

[1] Kirin Brewery Co Ltd, Pharmaceut Res Lab, Takasaki, Gumma 37012, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(97)10117-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 4-phenoxyquinolines, some of which showed potent and highly selective inhibitory activities for PDGF receptor autophosphorylation, was discovered. Interestingly, their structures were very similar to those of the selective inhibitors for EGF receptor autophosphorylation. (C) 1997 Elsevier Science Ltd.

引用

页码：2935 / 2940

页数：6

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