A-type potassium currents in smooth muscle

被引：74

作者：

Amberg, GC

Koh, SD

Imaizumi, YJ

Ohya, S

Sanders, KM ^{[1
]}

机构：

[1] Univ Nevada, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA

[2] Nagoya City Univ, Dept Mol & Cellular Pharmacol, Grad Sch Pharmaceut Sci, Nagoya, Aichi 4678603, Japan

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2003年 / 284卷 / 03期

关键词：

smooth muscle; Kv4; channels; potassium channel-interacting proteins;

D O I：

10.1152/ajpcell.00301.2002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A-type currents are voltage-gated, calcium-independent potassium (Kv) currents that undergo rapid activation and inactivation. Commonly associated with neuronal and cardiac cell-types, A-type currents have also been identified and characterized in vascular, genitourinary, and gastrointestinal smooth muscle cells. This review examines the molecular identity, biophysical properties, pharmacology, regulation, and physiological function of smooth muscle A-type currents. In general, this review is intended to facilitate the comparison of A-type currents present in different smooth muscles by providing a comprehensive report of the literature to date. This approach should also aid in the identification of areas of research requiring further attention.

引用

收藏

页码：C583 / C595

页数：13

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