Targeting of drugs and nanoparticles to tumors

被引：682

作者：

Ruoslahti, Erkki ^{[1
,2
]}

Bhatia, Sangeeta N. ^{[3
,4
,5
,6
,7
]}

Sailor, Michael J. ^{[8
,9
,10
]}

机构：

[1] Univ Calif Santa Barbara, Sanford Burnham Med Res Inst, Vasc Mapping Ctr, Santa Barbara, CA 93106 USA

[2] Sanford Burnham Med Res Inst, Canc Res Ctr, La Jolla, CA 92037 USA

[3] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[4] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[5] MIT, Robert Koch Inst, Cambridge, MA 02139 USA

[6] Brigham & Womens Hosp, Howard Hughes Med Inst, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Div Med, Boston, MA 02115 USA

[8] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[9] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[10] Univ Calif San Diego, Mat Sci & Engn Program, La Jolla, CA 92093 USA

来源：

JOURNAL OF CELL BIOLOGY | 2010年 / 188卷 / 06期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CELL-SURFACE; IN-VIVO; HOMING PEPTIDE; PHAGE DISPLAY; TISSUE FACTOR; MOUSE MODEL; ENDOTHELIAL-CELLS; VASCULAR MARKERS; AMINOPEPTIDASE N; QUANTUM DOTS;

D O I：

10.1083/jcb.200910104

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The various types of cells that comprise the tumor mass all carry molecular markers that are not expressed or are expressed at much lower levels in normal cells. These differentially expressed molecules can be used as docking sites to concentrate drug conjugates and nanoparticles at tumors. Specific markers in tumor vessels are particularly well suited for targeting because molecules at the surface of blood vessels are readily accessible to circulating compounds. The increased concentration of a drug in the site of disease made possible by targeted delivery can be used to increase efficacy, reduce side effects, or achieve some of both. We review the recent advances in this delivery approach with a focus on the use of molecular markers of tumor vasculature as the primary target and nanoparticles as the delivery vehicle.

引用

页码：759 / 768

页数：10

共 102 条

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