Antibiotic use and the prevalence of antibiotic resistance in bacteria from healthy volunteers in the Dutch community

被引:21
作者
Bruinsma, N
Stobberingh, E
de Smet, P
van den Bogaard, A
机构
[1] Univ Hosp Maastricht, Dept Med Microbiol, NL-6202 AZ Maastricht, Netherlands
[2] WINAp, Inst Pharmaceut Data, The Hague, Netherlands
关键词
D O I
10.1007/s15010-002-3035-8
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Although most antibiotics are consumed in the community (80%), the relation of antibiotic consumption and resistance in the community has not been thoroughly studied. Materials and Methods: In the present study, antibiotic use was related to the prevalence of antibiotic resistance of Escherichia coli and enterococci isolated from healthy volunteers Living in the southern part of the Netherlands in 1996 and 1999. Results: No change in the total antibiotic use in the Dutch community was observed between 1996 and 1999 (3,542 and 3,598 defined daily doses [DDD] per 1,000 inhabitants/year). However, the increased fluoroquinolone use (+ 18%) and the increased prevalence of ciprofloxacin resistance from 0 to 2% is a point of concern, especially since this was accompanied by a significant shift towards higher minimum inhibitory concentration (MIC) values (p < 0.05). A significant decrease in the prevalence of vancomycin-resistant enterococci (p < 0.05) was found in addition to a significant shift towards Lower MIC values for avoparcin, a glycopeptide previously used as growth promoter in animal husbandry (p < 0.05). This was very Likely due to the banning of avoparcin for this purpose from April 1997 onwards. Conclusion: In order to maintain the Low Level of antibiotic use and resistance in The Netherlands, surveillance of antibiotic resistance in nonclinical isolates in relation to antibiotic use is very important.
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页码:9 / 14
页数:6
相关论文
共 35 条
[1]   HIGH PREVALENCE OF ANTIBIOTIC-RESISTANT ESCHERICHIA-COLI IN FECAL SAMPLES OF STUDENTS IN THE SOUTH-EAST OF THE NETHERLANDS [J].
BONTEN, M ;
STOBBERINGH, E ;
PHILIPS, J ;
HOUBEN, A .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 (04) :585-592
[2]   Resistance of bacteria in urinary tract infections [J].
Chomarat, M .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (04) :483-487
[3]  
DENEELING AJ, 1997, VOLKSGEZONDHEID TOEK, P793
[4]   Emergence and dissemination of quinolone-resistant Escherichia coli in the community [J].
Garau, J ;
Xercavins, M ;
Rodríguez-Carballeira, M ;
Gómez-Vera, JR ;
Coll, I ;
Vidal, D ;
Llovet, T ;
Ruíz-Bremón, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2736-2741
[5]   Increasing resistance to fluoroquinolones in Escherichia coli from urinary tract infections in The Netherlands [J].
Goettsch, W ;
van Pelt, W ;
Nagelkerke, N ;
Hendrix, MGR ;
Buiting, AGM ;
Petit, PL ;
Sabbe, LJM ;
van Griethuysen, AJA ;
de Neeling, AJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (02) :223-228
[6]  
Gupta K, 1999, JAMA-J AM MED ASSOC, V282, P325
[7]   Molecular epidemiology of multi-resistant Escherichia coli [J].
Guyot, A ;
Barrett, SP ;
Threlfall, EJ ;
Hampton, MD ;
Cheasty, T .
JOURNAL OF HOSPITAL INFECTION, 1999, 43 (01) :39-48
[8]   The ECO•SENS Project:: a prospective, multinational, multicentre epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens -: interim report [J].
Kahlmeter, G .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 :15-22
[9]   Decreased incidence of VanA-type vancomycin-resistant enterococci isolated from poultry meat and from fecal samples of humans in the community after discontinuation of avoparcin usage in animal husbandry [J].
Klare, I ;
Badstübner, D ;
Konstabel, C ;
Böhme, G ;
Claus, H ;
Witte, W .
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1999, 5 (01) :45-52
[10]   Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community [J].
Klare, I ;
Heier, H ;
Claus, H ;
Bohme, G ;
Marin, S ;
Seltmann, G ;
Hakenbeck, R ;
Antanassova, V ;
Witte, W .
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE, 1995, 1 (03) :265-272