Regulation of Toll-like receptor signaling in the innate immunity

被引：53

作者：

An HuaZhang ^{[1
]}

Qian Cheng

Cao XueTao

机构：

[1] Second Mil Med Univ, Natl Key Lab Med Immunol, Shanghai 200433, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2010年 / 53卷 / 01期

关键词：

Toll-like receptors; TLR signaling; NF-KAPPA-B; DOMAIN-CONTAINING ADAPTER; I INTERFERON-PRODUCTION; NEGATIVE REGULATOR; PROINFLAMMATORY CYTOKINE; STRUCTURAL BASIS; CUTTING EDGE; INTERLEUKIN-1; RECEPTOR; SPLICE VARIANT; TIR-DOMAIN;

D O I：

10.1007/s11427-010-0011-x

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Toll-like receptors sense invading pathogens by recognizing a wide variety of conserved pathogen-associated molecular patterns (PAMPs). The members of TLR family selectively utilize adaptor proteins MyD88, TRIF, TIRAP and TRAM to activate overlapping but distinct signal transduction pathways which trigger production of different panels of mediators such as proinflammatory cytokines and type I interferon. These mediators not only control innate immunity but also direct subsequently developed adaptive immunity. TLR activation is strictly and finely regulated at multiple levels of the signal transduction pathways.

引用

页码：34 / 43

页数：10

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