Organic cation transporters in intestine, kidney, liver, and brain

被引：251

作者：

Koepsell, H ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Anat, D-97070 Wurzburg, Germany

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 1998年 / 60卷

关键词：

cation excretion; cation reabsorption; polyspecific transporters; drug transporters;

D O I：

10.1146/annurev.physiol.60.1.243

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

This review focuses on sodium-independent transport systems for organic cations in small intestine, liver, kidney, and brain. The roles of P-glycoproteins (MDR) and anion transporters (OATP) in organic cation transport are reported, and two members of the new transporter family OCT are described. The OCT transporters belong to a superfamily that includes multidrug-resistance proteins, facilitative diffusion systems, and proton antiporters. They mediate electrogenic transport of small organic cations with different molecular structures, independently of sodium and proton gradients. The current knowledge of the distribution and functional properties of cloned cation transport systems and of cation transport measured in intact plasma membranes is used to postulate identical or homologous transporters in intestine, liver, kidney, and brain.

引用

页码：243 / 266

页数：24

共 135 条

[1] REGULATION OF PLASMA CHOLINE BY RENAL TUBULE - BIDIRECTIONAL TRANSPORT OF CHOLINE [J].