For and against - Clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial

被引：120

作者：

Weijer, C ^{[1
]}

Shapiro, SH

Glass, KC

Enkin, MW

机构：

[1] Dalhousie Univ, Dept Bioeth, Halifax, NS B3H 4H7, Canada

[2] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ H3A 1A2, Canada

[3] McGill Univ, Dept Human Genet, Biomed Eth Unit, Montreal, PQ H3A 1A2, Canada

[4] McGill Univ, Dept Pediat, Biomed Eth Unit, Montreal, PQ H3A 1A2, Canada

来源：

BMJ-BRITISH MEDICAL JOURNAL | 2000年 / 321卷 / 7263期

关键词：

D O I：

10.1136/bmj.321.7263.756

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ethical basis for entering patients in randomised controlled trials is under debate, Some doctors espouse the uncertainty principle whereby randomisation to treatment is acceptable when an individual doctor is genuinely unsure which treatment is best for a patient. Others believe that clinical equipoise, reflecting collective professional uncertainty over treatment, is the soundest ethical criterion. Here doctors from two Canadian centres discuss their positions.

引用

页码：756 / 758

页数：3

共 11 条

[1] COLLINS R, 1992, INTRO NEW TREATMENTS
[2] EQUIPOISE AND THE ETHICS OF CLINICAL RESEARCH
FREEDMAN, B
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (03) : 141 - 145
[3] A study in contrasts: Eligibility criteria in a twenty-year sample of NSABP and POG clinical trials
Fuks, A
Weijer, C
Freedman, B
Shapiro, S
Skrutkowska, M
Riaz, A
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1998, 51 (02) : 69 - 79
[4] OF MICE BUT NOT MEN - PROBLEMS OF THE RANDOMIZED CLINICAL-TRIAL
HELLMAN, S
HELLMAN, DS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (22) : 1585 - 1589
[5] DESIGN AND ANALYSIS OF RANDOMIZED CLINICAL-TRIALS REQUIRING PROLONGED OBSERVATION OF EACH PATIENT .1. INTRODUCTION AND DESIGN
PETO, R
PIKE, MC
ARMITAGE, P
BRESLOW, NE
COX, DR
HOWARD, SV
MANTEL, N
MCPHERSON, K
PETO, J
SMITH, PG
[J]. BRITISH JOURNAL OF CANCER, 1976, 34 (06) : 585 - 612
[6] Trials: the next 50 years - Large scale randomised evidence of moderate benefits
Peto, R
Baigent, C
[J]. BMJ-BRITISH MEDICAL JOURNAL, 1998, 317 (7167): : 1170 - 1171
[7] EXPLANATORY AND PRAGMATIC ATTITUDES IN THERAPEUTICAL TRIALS
SCHWARTZ, D
LELLOUCH, J
[J]. JOURNAL OF CHRONIC DISEASES, 1967, 20 (08): : 637 - &
[8] PHYSICIANS REASONS FOR NOT ENTERING ELIGIBLE PATIENTS IN A RANDOMIZED CLINICAL-TRIAL OF SURGERY FOR BREAST-CANCER
TAYLOR, KM
MARGOLESE, RG
SOSKOLNE, CL
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (21) : 1363 - 1367
[9] Placebo-controlled trials in schizophrenia: Are they ethical? Are they necessary?
Weijer, C
[J]. SCHIZOPHRENIA RESEARCH, 1999, 35 (03) : 211 - 218
[10] Weijer C, 1999, J CLIN ETHIC, V10, P100

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